Clinical significance of ST3Gal IV expression in human renal cell carcinoma.

Abstract	Alteration of sialyltransferase expression has been implicated in carcinogenesis. Out of sialyltransferases cloned to date, we focused on ST3Gal IV expression in human renal cell carcinoma (RCC). Levels of ST3Gal IV mRNA were examined in human RCC in comparison with non-tumor kidney. ST3Gal IV cDNA obtained by polymerase chain reaction from cDNA library of human RCC cell line ACHN was identical to STZ in nucleotide sequence. Northern blot analysis was performed for 24 non-tumor kidney and 25 primary RCC tissues, and 5 metastases. ST3Gal IV mRNA level was decreased in 16 cases of 22 primary RCC tissues compared to 21 non-tumor kidney tissues. The mRNA level was low in 4 and equivocal in one, of 5 metastases. The 6 cases that possessed almost the same levels of ST3Gal IV mRNA in primary tumor tissues as those in non-tumor kidneys showed favorable prognoses, as assessed by Kaplan-Meier curve. These results indicate that down-regulation of ST3Gal IV mRNA may be one of the factors associated with the malignant progression of human RCC.
Authors	Seiichi Saito, Shin-Ichi Yamashita, Mareyuki Endoh, Takashi Yamato, Senji Hoshi, Chikara Ohyama, Ryuji Watanabe, Akihiro Ito, Makoto Satoh, Tadashi Wada, James C Paulson, Yoichi Arai, Taeko Miyagi
Journal	Oncology reports (Oncol Rep) 2002 Nov-Dec Vol. 9 Issue 6 Pg. 1251-5 ISSN: 1021-335X [Print] Greece
PMID	12375029 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	DNA Primers DNA, Complementary Isoenzymes RNA, Messenger Sialyltransferases beta-Galactoside alpha-2,3-Sialyltransferase
Topics	Adult Aged Animals COS Cells Carcinoma, Renal Cell (enzymology, genetics, pathology) Case-Control Studies Chlorocebus aethiops DNA Primers (chemistry) DNA, Complementary Down-Regulation Female Gene Expression Regulation, Enzymologic Humans Isoenzymes Kidney Neoplasms (enzymology, genetics, pathology) Male Middle Aged Neoplasm Staging Prognosis RNA, Messenger (metabolism) Reverse Transcriptase Polymerase Chain Reaction Sialyltransferases (genetics, metabolism) Transfection Tumor Cells, Cultured beta-Galactoside alpha-2,3-Sialyltransferase

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