Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268. | CureHunter

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Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268.

Abstract	The selective estrogen receptor modulator arzoxifene and the rexinoid LG 100268 were active not only as single agents for prevention and treatment of breast cancer in the rat model that uses nitrosomethylurea as the carcinogen but also showed striking synergy, both preventively and therapeutically, in a series of six experiments with a total of 465 rats. Mechanistic studies in cell culture reported here suggest that enhancement of stromal-epithelial interactions may contribute to this synergy. The possible clinical use of the combination of arzoxifene and LG 100268 for prevention of breast cancer in women at high risk, for treatment of women in the adjuvant setting, or for treatment of end-stage disease should now be considered.
Authors	Nanjoo Suh, William W Lamph, Andrew L Glasebrook, Timothy A Grese, Alan D Palkowitz, Charlotte R Williams, Renee Risingsong, M Rendi Farris, Richard A Heyman, Michael B Sporn
Journal	Clinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res) Vol. 8 Issue 10 Pg. 3270-5 (Oct 2002) ISSN: 1078-0432 [Print] United States
PMID	12374698 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References	Anticarcinogenic Agents Nicotinic Acids Piperidines Selective Estrogen Receptor Modulators Tetrahydronaphthalenes Thiophenes Transforming Growth Factor beta Methylnitrosourea LY 353381 NOS2 protein, human Nitric Oxide Synthase Nitric Oxide Synthase Type II Nos2 protein, rat LG 100268
Topics	Animals Anticarcinogenic Agents (therapeutic use) Cells, Cultured Drug Synergism Drug Therapy, Combination Female Humans Mammary Neoplasms, Experimental (metabolism, pathology, prevention & control) Methylnitrosourea Neoplasm Invasiveness Nicotinic Acids (therapeutic use) Nitric Oxide Synthase (metabolism) Nitric Oxide Synthase Type II Piperidines (therapeutic use) Rats Selective Estrogen Receptor Modulators (therapeutic use) Stromal Cells (metabolism) Tetrahydronaphthalenes (therapeutic use) Thiophenes (therapeutic use) Transforming Growth Factor beta (metabolism)

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