The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias.
Abstract | CONTEXT: OBJECTIVES: DESIGN: Diagnosis, HLA-DQ, clinical data, the multiple sleep latency test (MSLT), and CSF hypocretin-1 were studied in a case series of patients with sleep disorders from 1999 to 2002. Signal detection analysis was used to determine the CSF hypocretin-1 levels best predictive for International Classification of Sleep Disorders (ICSD)-defined narcolepsy (blinded criterion standard). Clinical and demographic features were compared in narcoleptic subjects with and without low CSF hypocretin-1 levels. SETTING:
Sleep disorder and neurology clinics in the United States and Europe, with biological testing performed at Stanford University, Stanford, Calif. PARTICIPANTS: INTERVENTION: Venopuncture for HLA typing, lumbar puncture for CSF analysis, primary diagnosis using the International Classification of Sleep Disorders, Stanford Sleep Inventory for evaluation of narcolepsy, and sleep recording studies. MAIN OUTCOME MEASURES: RESULTS: CONCLUSIONS:
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Authors | Emmanuel Mignot, Gert Jan Lammers, Beth Ripley, Michele Okun, Sonia Nevsimalova, Sebastiaan Overeem, Jitka Vankova, Jed Black, John Harsh, Claudio Bassetti, Harald Schrader, Seiji Nishino |
Journal | Archives of neurology
(Arch Neurol)
Vol. 59
Issue 10
Pg. 1553-62
(Oct 2002)
ISSN: 0003-9942 [Print] United States |
PMID | 12374492
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Biomarkers
- Carrier Proteins
- HCRT protein, human
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DQB1 antigen
- Intracellular Signaling Peptides and Proteins
- Membrane Glycoproteins
- Neuropeptides
- Neurotransmitter Agents
- Orexins
- Sympathomimetics
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Topics |
- Adult
- Biomarkers
(analysis)
- Carrier Proteins
(cerebrospinal fluid)
- Diagnosis, Differential
- Female
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- Histocompatibility Testing
- Humans
- Intracellular Signaling Peptides and Proteins
- Male
- Membrane Glycoproteins
- Middle Aged
- Narcolepsy
(diagnosis, pathology)
- Neuropeptides
(cerebrospinal fluid, deficiency)
- Neurotransmitter Agents
(cerebrospinal fluid, deficiency)
- Orexins
- Polysomnography
- Sensitivity and Specificity
- Sympathomimetics
(cerebrospinal fluid)
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