Hemostasis and fibrinolysis factors in first-degree relatives of patients with Type 2 diabetes without hypertension.

Abstract

First-degree relatives of type 2 diabetic patients with or without a family history of hypertension are at increased risk for cardiovascular diseases. The aim of this study was to verify some possible hemostatic alterations in first-degree relatives of type 2 diabetic, normotensive and hypertensive patients. In 78 non-diabetic, normotensive first-degree relatives of type 2 diabetic patients (47 without a family history of hypertension and 31 with a family history of hypertension) and in 36 normoglycemic, normotensive subjects with no family history of hypertension, we evaluated plasma levels of fasting glucose and insulin, tissue-type plasminogen activator (t-PA), plasminogen activator-inhibitor (PAI-1), D-dimer (DD) and prothrombin fragment 1 + 2 (F1+2). Insulin resistance, calculated by the HOMA model, and plasma levels of t-PA and PAI-1 were significantly higher in relatives of diabetics compared to controls. As far as the thrombin activation indexes are concerned, we detected a significant increase in DD and F1+2 in relatives of diabetics with hypertension compared to other study subjects. In conclusion, our data indicate that familial predisposition may influence the hemostatic system in first-degree relatives of diabetic and/or hypertensive patients.

• Authors: A Trifiletti, A Lasco, R Scamardi, M Cincotta, A Gaudio, N Barbera, N Frisina
• Journal: Pathophysiology of haemostasis and thrombosis (Pathophysiol Haemost Thromb) 2002 May-Jun Vol. 32 Issue 3 Pg. 127-30 ISSN: 1424-8832 [Print] Switzerland
• PMID: 12372926 (Publication Type: Journal Article)
• Copyright: Copyright 2002 S. Karger AG, Basel

Chemical References

• Biomarkers
• Blood Glucose
• Fibrin Fibrinogen Degradation Products
• Insulin
• Peptide Fragments
• Plasminogen Activator Inhibitor 1
• fibrin fragment D
• prothrombin fragment 1.2
• Prothrombin
• Tissue Plasminogen Activator

Topics

• Adult
• Biomarkers
• Blood Glucose (analysis)
• Cardiovascular Diseases (epidemiology, genetics)
• Comorbidity
• Diabetes Mellitus, Type 2 (epidemiology, genetics)
• Family
• Female
• Fibrin Fibrinogen Degradation Products (analysis)
• Fibrinolysis
• Genetic Predisposition to Disease
• Hemostasis
• Humans
• Hypertension (epidemiology)
• Insulin (blood)
• Insulin Resistance (genetics)
• Male
• Peptide Fragments (blood)
• Plasminogen Activator Inhibitor 1 (blood)
• Prothrombin
• Risk Factors
• Tissue Plasminogen Activator (blood)