Retrospective clinical comparison of Celsior solution to modified blood Wallwork solution in lung transplantation for cystic fibrosis.

Abstract

OBJECTIVE:

To compare the preservative effects of Celsior solution and modified blood Wallwork solution in lung transplantation.

METHODS:

From 1989 to 2000, 44 lung transplantations for cystic fibrosis were performed: 26 grafts were preserved with modified blood Wallwork solution and 18 with Celsior solution.

RESULTS:

Preoperative status of the 2 groups was similar. The ratio of arterial oxygen to fraction of inspired oxygen and the pulmonary vascular resistance on the first postoperative day did not differ significantly between the 2 groups. Early death was 4% (SD, 20%) in the Wallwork group versus 11% (SD, 32%) in the Celsior group (not significant). No death was related to graft failure. The forced expiratory volume in 1 second during the first month after transplantation was 63% (SD, 19%) in the Wallwork group versus 63% (SD, 16%) in the Celsior group (not significant).

CONCLUSION:

Because the solution does not need to be prepared on site and does not require blood from the donor, Celsior seems better than Wallwork solution for preserving lung grafts.

• Authors: O Baron, S Fabre, A Haloun, M Treilhaud, O al Habasch, D Duveau, J L Michaud, P Despins
• Journal: Progress in transplantation (Aliso Viejo, Calif.) (Prog Transplant) Vol. 12 Issue 3 Pg. 176-80 (Sep 2002) ISSN: 1526-9248 [Print] United States
• PMID: 12371042 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Albumins
• Celsior
• Chlorides
• Disaccharides
• Electrolytes
• Glutamates
• Organ Preservation Solutions
• Propionates
• Wallwork solution
• Mannitol
• Histidine
• Phosphoprotein Phosphatases
• Protein Tyrosine Phosphatases
• Glutathione

Topics

• Albumins (pharmacology)
• Chlorides (pharmacology)
• Cystic Fibrosis (surgery)
• Disaccharides (pharmacology)
• Electrolytes (pharmacology)
• Female
• Glutamates (pharmacology)
• Glutathione (pharmacology)
• Histidine (pharmacology)
• Humans
• Lung (drug effects, surgery)
• Lung Transplantation
• Male
• Mannitol (pharmacology)
• Organ Preservation Solutions (pharmacology)
• Phosphoprotein Phosphatases (pharmacology)
• Propionates (pharmacology)
• Protein Tyrosine Phosphatases (pharmacology)
• Retrospective Studies