| Abstract | Hyperthyroidism is characterized by increased levels of circulating free fatty acids (FFA) and increased lipid oxidation, but it is uncertain which regional fat depots contribute. The present study was designed to define the participation of femoral and abdominal fat stores in the overall stimulation of lipolysis in hyperthyroidism in the basal state and during insulin stimulation. We studied nine women with newly diagnosed hyperthyroidism (HT) and after (euthyroidism, ET) medical treatment with methimazol and compared with eight control subjects (CTR). All subjects were studied in the postabsorptive state and during a 3-h hyperinsulinemic euglycemic clamp with microdialysis catheters sc in the abdominal and femoral adipose tissue. Before treatment, patients had elevated circulating concentrations of triiodthyronine, FFA, and glycerol. Levels of interstitial glycerol ( micro mol/liter) in abdominal adipose tissue [485 +/- 24 (HT), 226 +/- 20 (ET) (P < 0.001), 265 +/- 34 (CTR) (P < 0.001)] and in femoral adipose tissue [468 +/- 41(HT), 245 +/- 29 (ET) (P < 0.01), 278 +/- 31(CTR) (P < 0.005)] were elevated in the basal hyperthyroid state, and these differences prevailed during the glucose clamp [230 +/- 23 (HT), 113 +/- 13 (ET) (P < 0.01), 132 +/- 22(CTR) (P < 0.01) and 303 +/- 39 (HT), 122 +/- 15 (ET) (P < 0.01), 166 +/- 21(CTR) (P < 0.01)]. These results suggest that femoral and abdominal adipose tissue contribute equally to the excessive rate of lipolysis in hyperthyroidism and that both tissues are resistant to the actions of insulin. |
| Authors | Anne Lene Dalkjaer Riis, Claus Højbjerg Gravholt, Christian Born Djurhuus, Helene Nørrelund, Jens Otto Lunde Jørgensen, Jørgen Weeke, Niels Møller
(Affiliation: Medical Department M (Endocrinology and Diabetes), Aarhus University Hospital and Institute of Experimental Clinical Science, Aarhus University, Aarhus 8000, Denmark. anne.lene.riis at iekf.au.dk)
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| Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 87
Issue 10
Pg. 4747-53
(Oct 2002)
ISSN: 0021-972X United States |
| PMID | 12364469
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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| Chemical References |
- Antithyroid Agents
- Fatty Acids, Nonesterified
- Glycerol
- Methimazole
- Triiodothyronine
|
| Topics |
- Abdomen
- Adipose Tissue
(blood supply, metabolism)
- Adult
- Antithyroid Agents
(therapeutic use)
- Blood Flow Velocity
- Energy Metabolism
- Fatty Acids, Nonesterified
(blood)
- Female
- Femur
- Food
- Glucose Clamp Technique
- Glycerol
(blood)
- Humans
- Hyperinsulinism
- Hyperthyroidism
(drug therapy, metabolism)
- Lipolysis
- Methimazole
(therapeutic use)
- Microdialysis
- Middle Aged
- Triiodothyronine
(blood)
|
