[Analysis of association of human endothelial nitric oxide synthase gene polymorphism with myocardial infraction].

Abstract

The aim of this study was an assessment of association of human endothelial nitric oxide synthase gene Ban II polymorphism with the myocardial infarction in 178 patients and 136 healthy individuals. These polymorphism were studied using polymerase chain reaction (PCR) and Ban II restriction fragment length polymorphism (RFLP). It was found that TT and GT genotypes and allele T were associated with myocardial infarction patients under 50 years. We did not observed this association for older myocardial infarction patients. Allele T might be used as a genetic marker in the prophylaxis of myocardial infarction among people under 50 years.

• Authors: Jacek Sobstyl, Grzegorz Dzida, Andrzej Puzniak, Jerzy Mosiewicz, Janusz Hanzlik
• Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (Pol Merkur Lekarski) Vol. 13 Issue 73 Pg. 10-3 (Jul 2002) ISSN: 1426-9686 [Print] Poland
• Vernacular Title: Analiza zwiazku polimorfizmu genu śródbłonkowej syntetazy tlenku azotu z zawałem mieśnia sercowego.
• PMID: 12362496 (Publication Type: English Abstract, Journal Article)

Chemical References

• Genetic Markers
• Nitrates
• Nitric Oxide
• NOS3 protein, human
• Nitric Oxide Synthase
• Nitric Oxide Synthase Type III
• Deoxyribonucleases, Type II Site-Specific
• GRGCYC-specific type II deoxyribonucleases

Topics

• Adult
• Age Factors
• Analysis of Variance
• Case-Control Studies
• Deoxyribonucleases, Type II Site-Specific (metabolism)
• Female
• Genetic Markers
• Genotype
• Humans
• Male
• Middle Aged
• Myocardial Infarction (blood, enzymology, genetics)
• Nitrates (blood)
• Nitric Oxide (blood)
• Nitric Oxide Synthase (genetics)
• Nitric Oxide Synthase Type III
• Poland
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Polymorphism, Restriction Fragment Length
• Risk Factors