[Fromilid (clarithromycin) in eradication patients in patients with duodenal ulcer associated with Helicobacter pylori (comparison of two treatment variations)].

Abstract

AIM:

Comparison of two treatment regimens of eradication treatment of duodenal ulcer (DU) associated with Helicobacter pylori based on fromilid (clarithromycin).

MATERIAL AND METHODS:

20 DU patients associated with HP were divided into two groups. 10 patients of group 1 received omeprazol, fromilid and metronidazol and 10 patients of group 2 were given omeprazol, fromilid and furasolidon for 7 days followed by 2-week omeprazol alone. The patients were examined clinically and endoscopically; HP were detected with a fast urease test and polymerase chain reaction before and after the treatment. Control examinations were performed 6 weeks after the medication.

RESULTS:

In group 1 duodenal healing was observed in all the 10 patients, HP eradication occurred in 9 of 10 patients by urease test and in 4 patients by PCR, in group 2 in 8 of 10, 10 of 10 and 10 of 10, respectively.

CONCLUSION:

Fromilid (clarithromycin) is effective in eradication treatment in combination with fromilid and metronidazol or furazolidon.

• Authors: Iu V Vasil'ev, L A Zvenigorodskaia, E V Kolomiets, V Iu Firsanova
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 74 Issue 8 Pg. 58-60 ( 2002) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Fromilid (klaritromitsin) v éradikatsionnoĭ terapii bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki, assotsiirovannoĭ s Helicobacter pylori (rezul'taty sopostavleniia dvukh variantov lecheniia).
• PMID: 12360599 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Metronidazole
• Clarithromycin
• Omeprazole

Topics

• Adolescent
• Adult
• Aged
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Clarithromycin (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Duodenal Ulcer (drug therapy, microbiology)
• Female
• Helicobacter Infections (drug therapy, microbiology)
• Helicobacter pylori (genetics, isolation & purification)
• Humans
• Male
• Metronidazole (administration & dosage, therapeutic use)
• Middle Aged
• Omeprazole (administration & dosage, therapeutic use)
• Polymerase Chain Reaction