Abstract |
The present study was undertaken to measure cerebrospinal fluid (CSF) levels of kynurenic acid (KYNA) in patients with relapsing-onset multiple sclerosis (MS) during remission or not progressing for at least 2 months. In these patients the levels of CSF KYNA were found to be significantly lower compared with subjects with non-inflammatory neurological diseases, as well as those with inflammatory disease (median (interquartile range): 0.41 (0.3-0.5) pmol/ml, n=26 vs. 0.67 (0.5-1.1), n=23, P<0.01 and 1.7 (1.5-2.6), n=16, P<0.001, respectively). These results provide further evidence of the alterations in the kynurenine pathway during remitting-onset MS.
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Authors | Konrad Rejdak, Halina Bartosik-Psujek, Beata Dobosz, Tomasz Kocki, Pawelz Grieb, Gavin Giovannoni, Waldemar A Turski, Zbigniew Stelmasiak |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 331
Issue 1
Pg. 63-5
(Oct 04 2002)
ISSN: 0304-3940 [Print] Ireland |
PMID | 12359324
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Female
- Humans
- Kynurenic Acid
(cerebrospinal fluid)
- Male
- Multiple Sclerosis, Chronic Progressive
(cerebrospinal fluid)
- Multiple Sclerosis, Relapsing-Remitting
(cerebrospinal fluid)
- Remission, Spontaneous
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