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Decreased level of kynurenic acid in cerebrospinal fluid of relapsing-onset multiple sclerosis patients.

Abstract
The present study was undertaken to measure cerebrospinal fluid (CSF) levels of kynurenic acid (KYNA) in patients with relapsing-onset multiple sclerosis (MS) during remission or not progressing for at least 2 months. In these patients the levels of CSF KYNA were found to be significantly lower compared with subjects with non-inflammatory neurological diseases, as well as those with inflammatory disease (median (interquartile range): 0.41 (0.3-0.5) pmol/ml, n=26 vs. 0.67 (0.5-1.1), n=23, P<0.01 and 1.7 (1.5-2.6), n=16, P<0.001, respectively). These results provide further evidence of the alterations in the kynurenine pathway during remitting-onset MS.
AuthorsKonrad Rejdak, Halina Bartosik-Psujek, Beata Dobosz, Tomasz Kocki, Pawelz Grieb, Gavin Giovannoni, Waldemar A Turski, Zbigniew Stelmasiak
JournalNeuroscience letters (Neurosci Lett) Vol. 331 Issue 1 Pg. 63-5 (Oct 04 2002) ISSN: 0304-3940 [Print] Ireland
PMID12359324 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Kynurenic Acid
Topics
  • Adult
  • Female
  • Humans
  • Kynurenic Acid (cerebrospinal fluid)
  • Male
  • Multiple Sclerosis, Chronic Progressive (cerebrospinal fluid)
  • Multiple Sclerosis, Relapsing-Remitting (cerebrospinal fluid)
  • Remission, Spontaneous

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