Abstract |
It is of interest whether the acetylcholinesterase inhibitor, 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone fumarate (TAK-147), can improve cognitive impairment caused by chronic cerebral ischemia in rats. Two weeks after four-vessel occlusion, apparent impairments of spatial retrieval memory were observed in the Morris water maze. Both TAK-147 at doses of 0.1, 0.3 and 1.0 mg/kg and donepezil at doses of 0.3 and 1.0 mg/kg significantly ameliorated ischemia-induced memory deficits dose-dependently, but tacrine had no appreciable effect. Furthermore, we demonstrate that the intensity of staining by 2,3,5-triphenyltetrazolium in the hippocampal and cortical slices was significantly decreased by ischemia (10 min anoxia/aglycemia), and that it was also significantly restored by treatment with TAK-147 and donepezil.
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Authors | A Jing Xu, Zhong Chen, Kazuhiko Yanai, Yu Wen Huang, Er Qing Wei |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 331
Issue 1
Pg. 33-6
(Oct 04 2002)
ISSN: 0304-3940 [Print] Ireland |
PMID | 12359317
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzazepines
- Cholinesterase Inhibitors
- Coloring Agents
- Indans
- Neuroprotective Agents
- Piperidines
- Tetrazolium Salts
- Tacrine
- triphenyltetrazolium
- TAK 147
- Donepezil
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Topics |
- Animals
- Benzazepines
(pharmacology)
- Brain
(drug effects)
- Brain Ischemia
(drug therapy, metabolism, physiopathology)
- Cholinesterase Inhibitors
(pharmacology)
- Coloring Agents
- Donepezil
- Dose-Response Relationship, Drug
- Indans
(pharmacology)
- Male
- Maze Learning
(drug effects)
- Neuroprotective Agents
(pharmacology)
- Organ Culture Techniques
- Piperidines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Tacrine
(pharmacology)
- Tetrazolium Salts
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