Contact sensitization of guinea-pigs with unsaturated and halogenated sultones.

Abstract

The sensitizing properties of unsaturated and halogenated sultones were examined in a guinea-pig model for contact hypersensitivity. The sensitization potential of 2-chloro-1,3-dodecanesultone was similar to that of 1-chloro-2,4-dinitrobenzene (DNCB). 2-bromo-1,3-dodecanesultone, 1-decene-1,3-sultone, 1-decene-1,3-sultone, 1-tetradecene-1,3-sultone and 1-hexadecene-1,3-sultone were stronger senistizers than DNCB. Ectensive cross-reactivity was observed among sultones of the same side-chain length, but differing from each other in being either unsaturated or halogenated. Extensive cross-reactivity was also noted among 4 unsaturated sultones of differing side-chain lengths. The inter-relationships among these sultones in regard to their immunogenic and tolerogenic properties are discussed.

• Authors: H L Ritz, D S Connor, E D Sauter
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 1 Issue 6 Pg. 349-58 (Dec 1975) ISSN: 0105-1873 [Print] England
• PMID: 1235293 (Publication Type: Journal Article)

Topics

• Animals
• Dermatitis, Contact (etiology)
• Female
• Guinea Pigs
• Male