Abstract |
The sensitizing properties of unsaturated and halogenated sultones were examined in a guinea-pig model for contact hypersensitivity. The sensitization potential of 2-chloro-1,3-dodecanesultone was similar to that of 1-chloro-2,4-dinitrobenzene ( DNCB). 2-bromo-1,3-dodecanesultone, 1-decene-1,3-sultone, 1-decene-1,3-sultone, 1-tetradecene-1,3-sultone and 1-hexadecene-1,3-sultone were stronger senistizers than DNCB. Ectensive cross-reactivity was observed among sultones of the same side-chain length, but differing from each other in being either unsaturated or halogenated. Extensive cross-reactivity was also noted among 4 unsaturated sultones of differing side-chain lengths. The inter-relationships among these sultones in regard to their immunogenic and tolerogenic properties are discussed.
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Authors | H L Ritz, D S Connor, E D Sauter |
Journal | Contact dermatitis
(Contact Dermatitis)
Vol. 1
Issue 6
Pg. 349-58
(Dec 1975)
ISSN: 0105-1873 [Print] England |
PMID | 1235293
(Publication Type: Journal Article)
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Topics |
- Animals
- Dermatitis, Contact
(etiology)
- Female
- Guinea Pigs
- Male
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