Orthotopic liver transplantation for unresectable hepatoblastoma.

Abstract

BACKGROUND:

The outcome of treatment for advanced hepatoblastoma has recently improved after the introduction of preoperative or pre- and postoperative cisplatin-containing chemotherapy combined with complete surgical excision. The role of liver transplantation in a population of patients who have received this regimen has not been clearly defined.

METHODS:

Orthotopic liver transplantation (OLT) was performed in 13 children, aged 5 months to 11 years (median 27 months), who were assessed with unresectable hepatoblastoma, and whose pretreatment extent-of-disease was based on radiologic findings of group III (n=11) and group IV (n=2). One child with a multifocal tumor showed pulmonary metastases at presentation, but, according to radiologic studies, the deposits resolved with chemotherapy before liver transplantation. One other child showed exophytic extension of the primary tumor infiltrating the porta hepatis and body of the pancreas. All 13 patients received preoperative chemotherapy to reduce the size of the primary tumor(s) and to treat metastatic spread.

RESULTS:

Twelve children underwent elective OLT; all are alive and show normal graft function at a mean follow-up of 33 months (range 1-108). One child shows evidence of recurrent disease in the form of pulmonary metastases. One child underwent emergency OLT for acute liver failure after (incomplete) extended right hepatectomy and died from respiratory failure, with no evidence of recurrent tumor 3 weeks posttransplant.

CONCLUSIONS:

Liver transplantation is an effective treatment for unresectable unifocal or multifocal hepatoblastoma confined to the liver. A multidisciplinary approach to the management of hepatoblastoma, with thoughtful collaboration between pediatric oncologists, hepatologists, and liver surgeons, is essential.

• Authors: Parthi Srinivasan, John McCall, Jon Pritchard, Anil Dhawan, Alistair Baker, Giorgina-Mieli Vergani, Paolo Muiesan, Mohamed Rela, Nigel David Heaton
• Journal: Transplantation (Transplantation) Vol. 74 Issue 5 Pg. 652-5 (Sep 15 2002) ISSN: 0041-1337 [Print] United States
• PMID: 12352881 (Publication Type: Journal Article)

Topics

• Adolescent
• Child
• Child, Preschool
• Graft Survival (physiology)
• Hepatoblastoma (pathology, secondary, surgery)
• Humans
• Liver Neoplasms (immunology, mortality, pathology, surgery)
• Liver Transplantation (mortality, pathology, physiology)
• Lung Neoplasms (secondary)
• Lymphocytes, Tumor-Infiltrating (immunology, pathology)
• Neoplasm Staging
• Survival Rate
• Time Factors
• Treatment Outcome