Abstract | PURPOSE: We present a comprehensive resource that summarizes contemporary advances relevant to the clinical management of renal angiomyolipoma. MATERIALS AND METHODS: RESULTS:
Angiomyolipoma is generally benign, although an uncommon subtype (epithelioid angiomyolipoma) may behave more aggressively. Tuberous sclerosis associated angiomyolipoma tends to be larger, multiple and more likely to cause spontaneous hemorrhage than the sporadic entity. Tumors that hemorrhage tend to be larger. Computerized tomography or magnetic resonance is usually sufficient for diagnosis. Biopsy is rarely useful. Primary indications for intervention include symptoms such as pain or bleeding or suspicion of malignancy. Prophylactic intervention is justifiable for large tumors, in females of childbearing age or in patients in whom followup or access to emergency care may be inadequate. Recent advances that have affected management include improved understanding of tuberous sclerosis complex and angiomyolipoma genetics, the identification of molecular markers that facilitate histopathological diagnosis, and the refinement of embolization and partial nephrectomy techniques. CONCLUSIONS: Although some cases of angiomyolipoma may require complete nephrectomy, most can be managed by conservative nephron sparing approaches. Ongoing research into the molecular biology and clinical behavior of angiomyolipoma may improve our ability to manage these lesions.
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Authors | Caleb P Nelson, Martin G Sanda |
Journal | The Journal of urology
(J Urol)
Vol. 168
Issue 4 Pt 1
Pg. 1315-25
(Oct 2002)
ISSN: 0022-5347 [Print] United States |
PMID | 12352384
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Angiomyolipoma
(diagnosis, genetics, therapy)
- Diagnostic Imaging
- Embolization, Therapeutic
- Female
- Genetic Markers
(genetics)
- Humans
- Kidney Neoplasms
(diagnosis, genetics, therapy)
- Male
- Nephrectomy
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