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Low-dose lamotrigine in West syndrome.

Abstract
Three infants affected with symptomatic West syndrome (WS), unresponsive to gamma-vinyl-GABA and to ACTH (first line drugs for WS), were rapidly cured with very small doses of lamotrigine (LTG). This suggests the advisability of a trial with low-dose LTG, at least in symptomatic WS resistant to one or two first line drugs. Moreover, it may be of speculative interest as regards pathogenetic mechanisms in some cases of WS.
AuthorsCarlo Cianchetti, Dario Pruna, Giangennaro Coppola, Antonio Pascotto
JournalEpilepsy research (Epilepsy Res) Vol. 51 Issue 1-2 Pg. 199-200 (Sep 2002) ISSN: 0920-1211 [Print] Netherlands
PMID12350395 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright 2002 Elsevier Science B.V.
Chemical References
  • Anticonvulsants
  • Triazines
  • Adrenocorticotropic Hormone
  • Vigabatrin
  • Lamotrigine
Topics
  • Adrenocorticotropic Hormone (therapeutic use)
  • Anticonvulsants (administration & dosage, therapeutic use)
  • Child, Preschool
  • Electroencephalography
  • Female
  • Humans
  • Infant
  • Lamotrigine
  • Magnetic Resonance Imaging
  • Male
  • Spasms, Infantile (drug therapy)
  • Treatment Outcome
  • Triazines (administration & dosage, therapeutic use)
  • Vigabatrin (therapeutic use)

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