Abstract |
Vitamin D analogues of high biological activity are probably useful in the treatment of renal osteodystrophy. The pharmacokinetics of the synthetic compound 5,6-trans-25-hydroxycholecalciferol have been studied in healthy subjects who were of normal vitamin D status. In comparison to natural 25-hydroxy-cholecalciferol, serum levels of the analogue were lower and its half-life in blood after oral or intravenous administration was considerably shorter. In normal subjects no increase of dihydroxylated metabolites in serum was observed within seven days of an intravenous dose.
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Authors | G Offermann, K Schaefer, H G Grigoleit, F Dittmar |
Journal | European journal of clinical pharmacology
(Eur J Clin Pharmacol)
Vol. 8
Issue 3-4
Pg. 255-60
(Apr 04 1975)
ISSN: 0031-6970 [Print] Germany |
PMID | 1233221
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Administration, Oral
- Adult
- Female
- Half-Life
- Humans
- Hydroxycholecalciferols
(administration & dosage, blood)
- Injections, Intravenous
- Kinetics
- Male
- Models, Biological
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