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The influence of polyglycolic acid (Dexon) on the formation of urinary calculi in rats fed with oxamide.

Abstract
Rats fed with 2% oxamide diet were considered as a model for the patient with a tendency to stone formation. Polyglycolic acid (Dexon) sary stream caused formation of oxamide deposits in a percentage as high as that observed with silk sutures. A high degree of toxicity was observed with the chosen concentration of oxamide diet (weight loss, mortality). The importance of oxamide concentration is underlined for further experiments on the influence of suture material on urinary infection and stone formation.
AuthorsP Strohmenger
JournalEuropean urology (Eur Urol) Vol. 1 Issue 5 Pg. 238-9 ( 1975) ISSN: 0302-2838 [Print] Switzerland
PMID1233190 (Publication Type: Journal Article)
Chemical References
  • Amino Acids
  • Polyglycolic Acid
  • Oxamic Acid
Topics
  • Amino Acids (administration & dosage)
  • Animal Feed
  • Animals
  • Dose-Response Relationship, Drug
  • Female
  • Oxamic Acid (administration & dosage, toxicity)
  • Polyglycolic Acid (adverse effects)
  • Rats
  • Sutures
  • Urinary Bladder (surgery)
  • Urinary Bladder Calculi (etiology)
  • Urinary Calculi (chemically induced)

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