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Dietary catechin delays tumor onset in a transgenic mouse model.

AbstractBACKGROUND:
Evidence exists that red wine, which contains a large array of polyphenols, is protective against cardiovascular disease and possibly cancer.
OBJECTIVE:
We tested the hypothesis that catechin, the major monomeric polyphenol in red wine, can delay tumor onset in transgenic mice that spontaneously develop tumors.
DESIGN:
Mice were fed a nutritionally complete amino acid-based diet supplemented with (+)-catechin (0-8 mmol/kg diet) or alcohol-free solids from red wine. Mice were examined daily; the age at which a first tumor appeared was recorded as the age at tumor onset. Plasma catechin and metabolite concentrations were quantified at the end of the study.
RESULTS:
Dietary catechin significantly delayed tumor onset; a positive, linear relation was observed between the age at tumor onset and either the amount of dietary catechin (r(2) = 0.761, P < 0.001) or plasma catechin and metabolite concentrations (r(2) = 0.408, P = 0.003). No significant effects on tumor onset were observed when mice consumed a diet supplemented with wine solids containing <0.22 mmol catechin/kg diet, whereas a previous study showed that wine solids with a similar total polyphenol concentration but containing approximately 4 times more catechin significantly delayed tumor onset by approximately 30 d compared with a control diet. The catechin composition of the wines is directly related to processing conditions during vinification.
CONCLUSIONS:
Physiologic intakes of specific dietary polyphenols, such as catechin, may play an important role in cancer chemoprevention. Wines have different polyphenol concentrations and compositions; therefore, the overall health benefits of individual wines differ.
AuthorsSusan E Ebeler, Charles A Brenneman, Gap-Soon Kim, William T Jewell, Michael R Webb, Leticia Chacon-Rodriguez, Emily A MacDonald, Amanda C Cramer, Andrew Levi, John D Ebeler, Alma Islas-Trejo, Amber Kraus, Steven H Hinrichs, Andrew J Clifford
JournalThe American journal of clinical nutrition (Am J Clin Nutr) Vol. 76 Issue 4 Pg. 865-72 (Oct 2002) ISSN: 0002-9165 [Print] United States
PMID12324302 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Amino Acids
  • Flavonoids
  • Phenols
  • Polymers
  • Catechin
Topics
  • Aging
  • Amino Acids (administration & dosage)
  • Animals
  • Catechin (administration & dosage, analysis, blood)
  • Diet
  • Female
  • Flavonoids
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Mice, Transgenic
  • Neoplasms (genetics, prevention & control)
  • Phenols (administration & dosage, analysis)
  • Polymers (administration & dosage, analysis)
  • Wine (analysis)

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