Abstract | BACKGROUND: OBJECTIVE: We tested the hypothesis that catechin, the major monomeric polyphenol in red wine, can delay tumor onset in transgenic mice that spontaneously develop tumors. DESIGN: Mice were fed a nutritionally complete amino acid-based diet supplemented with (+)- catechin (0-8 mmol/kg diet) or alcohol-free solids from red wine. Mice were examined daily; the age at which a first tumor appeared was recorded as the age at tumor onset. Plasma catechin and metabolite concentrations were quantified at the end of the study. RESULTS: Dietary catechin significantly delayed tumor onset; a positive, linear relation was observed between the age at tumor onset and either the amount of dietary catechin (r(2) = 0.761, P < 0.001) or plasma catechin and metabolite concentrations (r(2) = 0.408, P = 0.003). No significant effects on tumor onset were observed when mice consumed a diet supplemented with wine solids containing <0.22 mmol catechin/kg diet, whereas a previous study showed that wine solids with a similar total polyphenol concentration but containing approximately 4 times more catechin significantly delayed tumor onset by approximately 30 d compared with a control diet. The catechin composition of the wines is directly related to processing conditions during vinification. CONCLUSIONS: Physiologic intakes of specific dietary polyphenols, such as catechin, may play an important role in cancer chemoprevention. Wines have different polyphenol concentrations and compositions; therefore, the overall health benefits of individual wines differ.
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Authors | Susan E Ebeler, Charles A Brenneman, Gap-Soon Kim, William T Jewell, Michael R Webb, Leticia Chacon-Rodriguez, Emily A MacDonald, Amanda C Cramer, Andrew Levi, John D Ebeler, Alma Islas-Trejo, Amber Kraus, Steven H Hinrichs, Andrew J Clifford |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 76
Issue 4
Pg. 865-72
(Oct 2002)
ISSN: 0002-9165 [Print] United States |
PMID | 12324302
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Amino Acids
- Flavonoids
- Phenols
- Polymers
- Catechin
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Topics |
- Aging
- Amino Acids
(administration & dosage)
- Animals
- Catechin
(administration & dosage, analysis, blood)
- Diet
- Female
- Flavonoids
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Transgenic
- Neoplasms
(genetics, prevention & control)
- Phenols
(administration & dosage, analysis)
- Polymers
(administration & dosage, analysis)
- Wine
(analysis)
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