Abstract | OBJECTIVES: DESIGN: MATERIALS AND METHODS: venous blood samples were collected before and 2h after smoking one cigarette (0.9mg nicotine). Plasma concentrations (pg/ml) of dihydroxiphenylalanine (pL- DOPA), noradrenalin (pNA), adrenalin (pAD) and 3,4-dihydroxiphenylacetic acid (pDOPAC) were determined. RESULTS: Buerger's patients have low basal plasma catecholamines compared to volunteers: pNA (501 (196-927) vs 1858 (968-3663)) and pAD (71 (31-109) vs 193 (116-334)). Sympathectomy increased pL- DOPA, pAD and pDOPAC, but not pNA. After smoking, pNA only decreased in volunteers (1858 (968-3663) vs 1064 (535-2393)). In Buerger+sympathectomy group, smoking lowered pAD (700 (58-3379) vs 278 (54-429)). CONCLUSIONS: in Buerger's disease there is an impairment of sympathoadrenal function with an altered peripheral adrenergic response to cigarette smoking. Patients submitted to sympathectomy have high pAD, but this benefit is reversed after smoking. This might be clinically relevant given the association between cigarette smoking and the manifestations of Buerger's disease and the controversy on the effectiveness of sympathectomy in the management of the disease.
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Authors | R Roncon-Albuquerque, P Serrão, R Vale-Pereira, J Costa-Lima, R Roncon-Albuquerque Jr |
Journal | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
(Eur J Vasc Endovasc Surg)
Vol. 24
Issue 4
Pg. 338-43
(Oct 2002)
ISSN: 1078-5884 [Print] England |
PMID | 12323177
(Publication Type: Journal Article)
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Chemical References |
- Catecholamines
- Ganglionic Stimulants
- Nicotine
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Topics |
- Adrenal Glands
(drug effects, metabolism)
- Adult
- Age Factors
- Catecholamines
(blood)
- Female
- Ganglionic Stimulants
(pharmacology)
- Humans
- Lumbosacral Plexus
(surgery)
- Male
- Middle Aged
- Nicotine
(pharmacology)
- Smoking
(adverse effects)
- Sympathectomy
- Sympathetic Nervous System
(drug effects, metabolism)
- Thromboangiitis Obliterans
(blood, surgery)
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