[Chemotherapeutic activity of bonafton in experimental herpetic keratitis in rabbits].

Abstract

Bonaphthone (6-naphthoquinone-1,2) administered per os produces a prounced therapeutic effect in experimental herpetic keratitis of rabbits, induced by the virus of herpes simplex. With the topical appllication of bonaphthone in the form of an ointment the drug also produces a curative action in herpetic keratitis of rabbits. Combined application of bonaphthone locally and enterally in dealing with herpes in rabbits also acts beneficially, the same as its separate use.

• Authors: N S Bogdanova, I S Nikolaeva, G N Pershin
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1975 Nov-Dec Vol. 38 Issue 6 Pg. 728-32 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Khimioterapevticheskaia aktivnost' bonaftona pri éksperimental'nom gerpeticheskom keratite krolikov
• PMID: 1227924 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antiviral Agents
• Naphthoquinones
• Ointments
• Ophthalmic Solutions
• Idoxuridine

Topics

• Administration, Oral
• Administration, Topical
• Animals
• Antiviral Agents (administration & dosage, therapeutic use)
• Drug Evaluation, Preclinical
• Drug Therapy, Combination
• Idoxuridine (therapeutic use)
• Keratitis, Dendritic (drug therapy)
• Naphthoquinones (administration & dosage, therapeutic use)
• Ointments
• Ophthalmic Solutions
• Rabbits
• Time Factors