[Effect of naphthenic acids on the permeability of ascitic tumor cells to potassium ions].

Abstract

Ascite cells were treated with naphthenic acid preparation, containing a mixture of naphthenic acids with average molecular weight equal to 240, and with a fraction of this preparation differing in the boiling temperature. A 5-10(-7)M and higher concentrations of the preparation and its fraction brought about an increased permeability in ascite cells for K-ions. The effectiveness of naphthenic acids is associated with their hydrophobic properties, which was characterized in the present communication by the value of hydrophilic-lipophilic balance calculated according to the Davies formula.

• Authors: G G Slivinskiĭ, A F Artamonov, M I Goriaev
• Journal: Tsitologiia (Tsitologiia) Vol. 17 Issue 11 Pg. 1283-8 (Nov 1975) ISSN: 0041-3771 [Print] Russia (Federation)
• Vernacular Title: Vliianie naftenovykh kislot na pronitsaemost' astsitnykh opukholevykh kletok dlia ionov kaliia
• PMID: 1226561 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cyclohexanecarboxylic Acids
• Surface-Active Agents
• Potassium

Topics

• Animals
• Carcinoma, Ehrlich Tumor (metabolism)
• Cell Membrane Permeability (drug effects)
• Cyclohexanecarboxylic Acids (pharmacology)
• Mice
• Neoplasm Transplantation
• Potassium (metabolism)
• Surface-Active Agents (pharmacology)