Histology of chemically induced mesotheliomas in MRC-Wistar rats.

Abstract	Two peritoneal mesotheliomas were induced in rats during a carcinogenicity study of 1-nitroso-5,6-dihydrouracil (NO-DHU) injected intraperitoneally. A review of literature concerning experimental induction of such tumors indicated that they seldom produced with organic compounds and rarely occur spontaneously. In the present study, several reports of chemically induced mesotheliomas of the testes are analyzed and the diagnoses critically reviewed along with other differential diagnoses.
Authors	A Pelfrene, H Garcia
Journal	Tumori (Tumori) 1975 Nov-Dec Vol. 61 Issue 6 Pg. 509-15 ISSN: 0300-8916 [Print] United States
PMID	1224394 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Carcinogens Nitrosamines Nitroso Compounds 1-nitroso-5,6-dihydrouracil Uracil
Topics	Animals Carcinogens Male Mesothelioma (chemically induced) Neoplasms, Experimental (chemically induced) Nitrosamines Nitroso Compounds Peritoneal Neoplasms (chemically induced) Rats Uracil (analogs & derivatives)

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