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Progestin binding in testes from three siblings with the syndrome of male pseudohermaphroditism with testicular feminization.

Abstract
We have found a specific binding protein for synthetic progestins 6,7-[3H]methyltrienolone (R1881) and 17,21-dimethyl-19-norpregna-4,9-diene-3,20-dione (R5020) and in the testis cytosol from three "sisters" with the complete form of the testicular feminization syndrome. The binding component sediments in the 8S region of sucrose gradients. It is saturable. The apparent affinity constant (Ka) for R5020 was determined in two cases and found to be 1.8 and 0.6 X 10(8) M-1. The number of binding sites calculated from Scatchard plots is relatively high: 572 and 826 fmol/mg protein. Competition studies indicate that this putative receptor is specific for natural and synthetic progestins but not for 5 alpha-dihydrotestosterone and cortisol. Similar progestin binding could not be found in normal human and rat testes.
AuthorsJ Y Dube, P Chapdelaine, F T Dionne, D Cloutier, R R Tremblay
JournalThe Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 47 Issue 1 Pg. 41-5 (Jul 1978) ISSN: 0021-972X [Print] United States
PMID122397 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Estrenes
  • Receptors, Progesterone
  • Testosterone Congeners
  • Metribolone
  • Testosterone
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Promegestone
Topics
  • Adult
  • Animals
  • Disorders of Sex Development (complications, genetics, metabolism)
  • Estrenes (metabolism)
  • Female
  • Feminization (complications, metabolism)
  • Follicle Stimulating Hormone (blood)
  • Humans
  • Luteinizing Hormone (blood)
  • Male
  • Metribolone
  • Middle Aged
  • Promegestone (metabolism)
  • Rats
  • Rats, Inbred Strains
  • Receptors, Progesterone (metabolism)
  • Testis (metabolism)
  • Testosterone (blood)
  • Testosterone Congeners (metabolism)

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