Abstract | BACKGROUND: MATERIALS AND METHODS: RESULTS: The NE carcinoma and endothelial cells expressed sst. Octreotide induced NE carcinoma to apoptosis in vitro and in vivo. Octreotide-treated tumors had a massive necrotic area (62.7 +/- 19.3% treated vs. 39.7 +/- 20.34% untreated, p < 0.05). Microvessels in the treated tumor were decreased (264.0 +/- 48.2/mm(2) treated vs. 341.4 +/- 56.6/mm(2) untreated, p < 0.05). The plasma levels of VEGF and bFGF were reduced by octreotide. CONCLUSIONS:
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Authors | Michihiro Koizumi, Masahiko Onda, Noritake Tanaka, Tomoko Seya, Takeshi Yamada, Yoshiyuki Takahashi |
Journal | Digestion
(Digestion)
Vol. 65
Issue 4
Pg. 200-6
( 2002)
ISSN: 0012-2823 [Print] Switzerland |
PMID | 12239460
(Publication Type: Journal Article)
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Copyright | Copyright 2002 S. Karger AG, Basel |
Chemical References |
- Angiogenesis Inhibitors
- Antineoplastic Agents, Hormonal
- Endothelial Growth Factors
- Intercellular Signaling Peptides and Proteins
- Lymphokines
- Receptors, Somatostatin
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Fibroblast Growth Factors
- Octreotide
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Topics |
- Angiogenesis Inhibitors
(pharmacology, therapeutic use)
- Animals
- Antineoplastic Agents, Hormonal
(pharmacology, therapeutic use)
- Apoptosis
(drug effects)
- Carcinoma, Neuroendocrine
(drug therapy, metabolism)
- Endothelial Growth Factors
(blood)
- Female
- Fibroblast Growth Factors
(blood)
- Humans
- Immunohistochemistry
- In Situ Nick-End Labeling
- Intercellular Signaling Peptides and Proteins
(blood)
- Lymphokines
(blood)
- Mice
- Mice, Nude
- Middle Aged
- Necrosis
- Octreotide
(pharmacology, therapeutic use)
- Receptors, Somatostatin
(metabolism)
- Rectal Neoplasms
(drug therapy, metabolism)
- Transplantation, Heterologous
- Tumor Cells, Cultured
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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