(+)-Tiliarine, a selective in vitro inhibitor of human melanoma cells.

Abstract

Five diphenylbisbenzylisoquinoline (DBBI) alkaloids, tiliacorinine, tiliacorine, nor- tiliacorinine A, tiliarine and tiliamosine were isolated from the ethanol extract of the roots of Tiliacora racemosa Colebr. and identified by spectral techniques. Of these (+)-tiliarine is the only one which exhibited a selective inhibitory effect against human melanoma cells (G 361) and had no activity on normal human fibroblasts (CCD 974 SK). The activity of (+)-tiliarine against the human melanoma cell line was not much modified in the presence of calcium chloride.

• Authors: Tapan Seal, Biswapati Mukherjee
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 16 Issue 6 Pg. 596-9 (Sep 2002) ISSN: 0951-418X [Print] England
• PMID: 12237824 (Publication Type: Journal Article)
• Copyright: Copyright 2002 John Wiley & Sons, Ltd.

Chemical References

• Alkaloids
• Antineoplastic Agents, Phytogenic
• Heterocyclic Compounds, 4 or More Rings
• Plant Extracts
• tiliarine
• Calcium Chloride

Topics

• Alkaloids (pharmacology)
• Antineoplastic Agents, Phytogenic (pharmacology)
• Calcium Chloride (pharmacology)
• Cell Line
• Dose-Response Relationship, Drug
• Fibroblasts (drug effects)
• Heterocyclic Compounds, 4 or More Rings (chemistry, pharmacology)
• Humans
• Melanoma (drug therapy, pathology)
• Menispermaceae
• Molecular Structure
• Plant Extracts (chemistry, pharmacology)
• Plant Roots (chemistry)
• Spectrophotometry, Ultraviolet
• Tumor Cells, Cultured (drug effects)