New biologically active marine sesquiterpenoid and steroid from the okinawan sponge of the genus Axinyssa.

Abstract

A new bisabolane-type sesquiterpenoid, (E)-3-isocyanobisabolane-7,10-diene (1), and a new epidioxyergostane-type steroid, 9(11)-dehydroaxinysterol (2), were isolated from the Okinawan sponge of the genus Axinyssa. Their structures were elucidated based on the results of spectroscopic analysis and chemical conversion. Epidioxysterol 2 was found to show significant growth inhibitory effects against human cancer cell lines.

• Authors: Makoto Iwashima, Ikuo Terada, Kazuo Iguchi, Takao Yamori
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 50 Issue 9 Pg. 1286-9 (Sep 2002) ISSN: 0009-2363 [Print] Japan
• PMID: 12237556 (Publication Type: Journal Article)

Chemical References

• Alkenes
• Antineoplastic Agents
• Sesquiterpenes
• Steroids
• Ergosterol

Topics

• Alkenes (chemistry)
• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Artemia
• Catalysis
• Drug Screening Assays, Antitumor
• Ergosterol (chemistry, isolation & purification)
• Humans
• Hydrogenation
• Japan
• Lethal Dose 50
• Magnetic Resonance Spectroscopy
• Mass Spectrometry
• Models, Molecular
• Oxidation-Reduction
• Porifera (chemistry)
• Sesquiterpenes (chemistry, isolation & purification, pharmacology)
• Steroids (chemistry, isolation & purification, pharmacology)