Comparative studies of the efficacy of parvaquone and parvaquone-plus-frusemide in the treatment of Theileria parva infection (East Coast fever) in cattle.

Abstract

Comparative studies of the efficacy of parvaquone (Parvexon) and parvaquone-plus-frusemide (Fruvexon) Bimeda Chemicals, Ireland, were done on 60 naturally infected cases of East Coast fever (ECF; Theileria parva infection in cattle). Small-scale dairy farmers in the peri-urban of Dar Es Salaam city reported ECF-suspected cases from March to mid-October 2001 and were treated with the two drugs alternately, as were diagnosed positive for ECF. Four sub-groups of 15 cattle each (early stage, 15; advanced stage, 15) were treated with parvaquone and parvaquone-plus-frusemide. Twenty-eight out of 30 (93.3%) cattle treated with parvaquone-plus-frusemide were cured, so do 24 out of 30 (80.0%) cattle treated with parvaquone without frusemide. Early diagnosis and prompt management of pulmonary signs, which accounted for 30.0% of total ECF cases is advised in order to improve cure rates. Unlike parvaquone without frusemide (Parvexon), parvaquone-plus-frusemide (Fruvexon) proved useful in the management of pulmonary signs, hence, a drug of choice in the treatment of ECF cases that are accompanied by or are likely to manifest pulmonary signs.

• Authors: H A Mbwambo, F F Sudi, P A Mkonyi, J M Mfinanga, E S Mella, C J Ngovi
• Journal: Veterinary parasitology (Vet Parasitol) Vol. 108 Issue 3 Pg. 195-205 (Sep 26 2002) ISSN: 0304-4017 [Print] Netherlands
• PMID: 12237138 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antiprotozoal Agents
• Diuretics
• Drug Combinations
• Naphthoquinones
• Furosemide
• parvaquone

Topics

• Age Factors
• Animals
• Antiprotozoal Agents (administration & dosage, therapeutic use)
• Body Temperature
• Cattle
• Cattle Diseases (drug therapy, parasitology)
• Diuretics (administration & dosage, standards, therapeutic use)
• Drug Combinations
• Female
• Furosemide (administration & dosage, standards, therapeutic use)
• Male
• Naphthoquinones (administration & dosage, standards, therapeutic use)
• Parasitemia (drug therapy, veterinary)
• Sex Factors
• Suburban Population
• Tanzania
• Theileria parva (growth & development, metabolism)
• Theileriasis (drug therapy, parasitology)