Abstract | BACKGROUND: AIM: To evaluate the efficacy of different doses of lansoprazole for the treatment of functional dyspepsia in Chinese patients. METHOD: Patients with a clinical diagnosis of functional dyspepsia according to the Rome II criteria and normal upper gastrointestinal endoscopy were recruited and randomised to receive: (1) lansoprazole 30 mg, (2) lansoprazole 15 mg, or (3) placebo, all given daily for four weeks. Dyspepsia symptom scores and quality of life (SF-36 score) were evaluated before and four weeks after treatment. RESULTS: A total of 453 patients were randomised. There was no difference in the proportion of patients with complete symptom relief in the lansoprazole 30 mg (23%) and lansoprazole 15 mg (23%) groups compared with the placebo group (30%). The proportion of H pylori positive patients with a complete response was similar with lansoprazole 30 mg (34%) and lansoprazole 15 mg (20%) versus placebo (22%). All symptom subgroups ( ulcer-like, dysmotility-like, reflux-like, and unspecified dyspepsia) had similar proportions of patients with complete symptom relief after treatment. CONCLUSION:
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Authors | W M Wong, B C Y Wong, W K Hung, Y K Yee, A W C Yip, M L Szeto, F M Y Fung, T S M Tong, K C Lai, W H C Hu, M F Yuen, S K Lam |
Journal | Gut
(Gut)
Vol. 51
Issue 4
Pg. 502-6
(Oct 2002)
ISSN: 0017-5749 [Print] England |
PMID | 12235071
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Anti-Bacterial Agents
- Anti-Ulcer Agents
- Lansoprazole
- Omeprazole
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Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Adolescent
- Adult
- Aged
- Anti-Bacterial Agents
(adverse effects, therapeutic use)
- Anti-Ulcer Agents
(therapeutic use)
- China
- Double-Blind Method
- Drug Administration Schedule
- Dyspepsia
(complications, drug therapy, microbiology)
- Female
- Helicobacter Infections
(complications)
- Helicobacter pylori
- Humans
- Lansoprazole
- Male
- Middle Aged
- Omeprazole
(adverse effects, analogs & derivatives, therapeutic use)
- Quality of Life
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