Efficacy of lithium treatment in Kleine-Levin syndrome.

Abstract

The Kleine-Levin syndrome (KLS) is characterized by periodic, sudden-onset episodes of hypersomnia, compulsive hyperphagia, and behavioral-emotional symptoms, lasting from a few days to a few weeks, with complete remission in the intercritical periods. We report on efficacy of lithium treatment in a highly recurring form of the disorder in a 17-year-old male adolescent. The decreasing severity of the disorder paralleled the progressive increase of lithium dosage, up to 0.9 mEq l(-1). Implications regarding the pharmacological treatment of this neglected disorder are discussed.

• Authors: F Muratori, N Bertini, G Masi
• Journal: European psychiatry : the journal of the Association of European Psychiatrists (Eur Psychiatry) Vol. 17 Issue 4 Pg. 232-3 (Jul 2002) ISSN: 0924-9338 [Print] England
• PMID: 12231271 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antimanic Agents
• Lithium Carbonate

Topics

• Adolescent
• Antimanic Agents (therapeutic use)
• Compulsive Behavior (complications, drug therapy)
• Disorders of Excessive Somnolence (complications, drug therapy)
• Humans
• Hyperphagia (complications, drug therapy)
• Lithium Carbonate (therapeutic use)
• Male
• Mental Disorders (complications, drug therapy)
• Syndrome