Effects of NMDA antagonist MK-801 on radial maze performance in Zucker rats.

We examined the participation of the NMDA receptor in the histaminergic system using radial maze performance in Zucker rats. Although pyrilamine caused a significant effect on spatial memory deficit in lean rats, no significant spatial memory deficit was observed in obese rats. On the other hand, MK-801 caused significant spatial memory deficits in obese rats in comparison with lean rats. These results indicate that the histaminergic neuron is not closely related with the radial maze performance in obese rats. In addition, the potent effect of MK-801 observed in obese rats compared with lean rats may be responsible for the activation of NMDA receptors in obese rats.
AuthorsMiyuki Nishiga, Yoko Fujii, Yukio Sugimoto, Masako Konishi, Chiaki Kamei
JournalBrain research (Brain Res) Vol. 950 Issue 1-2 Pg. 127-9 (Sep 20 2002) ISSN: 0006-8993 [Print] Netherlands
PMID12231236 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Excitatory Amino Acid Antagonists
  • Receptors, N-Methyl-D-Aspartate
  • Dizocilpine Maleate
  • Animals
  • Dizocilpine Maleate (pharmacology)
  • Dose-Response Relationship, Drug
  • Excitatory Amino Acid Antagonists (pharmacology)
  • Male
  • Maze Learning (drug effects, physiology)
  • Rats
  • Rats, Zucker
  • Receptors, N-Methyl-D-Aspartate (antagonists & inhibitors, physiology)
  • Species Specificity

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