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Regression of prostate cancer following administration of Genistein Combined Polysaccharide (GCP), a nutritional supplement: a case report.

AbstractPURPOSE:
It has been reported that genistein, an isoflavone used in soybeans, has antiprostate cancer effects. Genistein Combined Polysaccharide (GCP trade mark; AMino Up, Sapporo, Japan), a nutritional supplement manufactured in Japan, is composed of genistein and a polysaccharide obtained from basidiomycetes (mycelia) that grows in a variety of mushrooms.
METHODS:
We report a case of a patient with a biopsy proven prostate cancer showing clinical and pathologic evidence of regression following administration of GCP. The patient was enrolled in an Institutional Review Board (IRB)-approved protocol and received GCP for 6 weeks prior to radical prostatectomy.
RESULTS:
The patient's prostate-specific antigen (PSA) decreased from an initial value of 19.7 to 4.2 ng/mL after 44 days of low-dose GCP. No cancer was identified in the radical prostatectomy specimen and no side effects were observed in this patient.
CONCLUSION:
This case suggests that GCP, which has shown potent inhibitory effects against prostate cancer in vitro, may have some potential activity in the treatment and prevention of prostate cancer.
AuthorsMohamed A Ghafar, Erica Golliday, Jonathan Bingham, Mahesh M Mansukhani, Aristotelis Georgios Anastasiadis, Aaron E Katz
JournalJournal of alternative and complementary medicine (New York, N.Y.) (J Altern Complement Med) Vol. 8 Issue 4 Pg. 493-7 (Aug 2002) ISSN: 1075-5535 [Print] United States
PMID12230910 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Polysaccharides
  • Genistein
  • Prostate-Specific Antigen
Topics
  • Antineoplastic Agents (pharmacology, therapeutic use)
  • Basidiomycota
  • Biomarkers, Tumor (blood)
  • Dose-Response Relationship, Drug
  • Genistein (pharmacology, therapeutic use)
  • Humans
  • Lentinula
  • Male
  • Middle Aged
  • Mycelium
  • Polysaccharides (therapeutic use)
  • Prostate-Specific Antigen (blood)
  • Prostatic Neoplasms (drug therapy, immunology, pathology)
  • Reishi
  • Remission Induction
  • Treatment Outcome

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