[Successful salvage chemotherapy with gemcitabine, etoposide and cisplatin for metastatic ureteral cancer: a case report].

Abstract

A 35-year-old man who had undergone nephroureterectomy and a single cycle of adjuvant MVAC chemotherapy for the left ureteral cancer was referred our clinic for the treatment of paraaortic lymph node metastases. Following histologic confirmation of transitional cell carcinoma by computed tomography (CT) guided biopsy, we treated him with combination chemotherapy consisting of ifosfamide, 5-fluorouracil, etoposide and cisplatin. After 5 cycles of chemotherapy complete remission was obtained. Six months later, however, metastases recurred in the left supraclavicular and paraaortic lymph nodes. Thus, we treated him with a new combination chemotherapy comprising gemcitabine, etoposide and cisplatin which was approved as a phase I study by the institutional review board. Although he was the first patient enrolled in the study and received the minimum dose of gemcitabine (level 1), complete remission was again achieved. Adjuvant radiotherapy of 40 Gy was given to the metastatic sites. He has been well without evidence of disease for 12 months.

• Authors: Tetsuro Tsukamoto, Junji Yonese, Nobuyuki Ishii, Takuya Maezawa, Iwao Fukui
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 48 Issue 7 Pg. 427-30 (Jul 2002) ISSN: 0018-1994 [Print] Japan
• PMID: 12229181 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Deoxycytidine
• Etoposide
• Cisplatin
• Gemcitabine

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Transitional Cell (therapy)
• Cisplatin (administration & dosage)
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Etoposide (administration & dosage)
• Humans
• Lymphatic Metastasis
• Male
• Radiotherapy, Adjuvant
• Remission Induction
• Salvage Therapy
• Treatment Outcome
• Ureteral Neoplasms (therapy)
• Gemcitabine