Alpha-glucosidase inhibitory activity of a 70% methanol extract from ezoishige (Pelvetia babingtonii de Toni) and its effect on the elevation of blood glucose level in rats.

Abstract	The 70% methanol extract from ezoishige (Pelvetia babingtonii de Toni) inhibited the rat-intestinal alpha-glucosidase, sucrase and maltase activities, with IC50 values of 2.24 and 2.84 mg/ml. Sucrose was orally administered with or without the extract to rats at 1000 mg/kg. The postprandial elevation in the blood glucose level at 15 and 30 min after the administration of sucrose with the extract was significantly suppressed when compared with the control. These results suggest that the extract from ezoishige has potent alpha-glucosidase inhibitors and would be effective for suppressing postprandial hyperglycemia.
Authors	Tomoki Ohta, Shigefumi Sasaki, Tadashi Oohori, Shuji Yoshikawa, Hideyuki Kurihara
Journal	Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 66 Issue 7 Pg. 1552-4 (Jul 2002) ISSN: 0916-8451 [Print] England
PMID	12224640 (Publication Type: Journal Article)
Chemical References	Blood Glucose Enzyme Inhibitors Glycoside Hydrolase Inhibitors Hypoglycemic Agents Solvents Sucrose Sucrase Methanol
Topics	Animals Blood Glucose (metabolism) Dose-Response Relationship, Drug Enzyme Inhibitors (pharmacology) Glycoside Hydrolase Inhibitors Hypoglycemic Agents (pharmacology) Intestines (drug effects, enzymology) Kinetics Male Methanol Phaeophyta (chemistry) Postprandial Period (drug effects) Rats Rats, Wistar Solvents Sucrase (antagonists & inhibitors) Sucrose (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!