[Initial scleromyxedema. Successful treatment with melphalan].

Abstract

Scleromyxedema is a rare mucinous disease without thyroid dysfunction, associated with a monoclonal gammopathy. The deposits of mucin in the skin and other organs such as the cardiovasculary system, determine the prognosis of the disease. A 74-year old patient with initial scleromyxedema is described, in whom a pulse therapy with melphalan was initiated already in the early stages of the disease. Four cycles of melphalan in combination with prednisolon led to a complete and sofar stable remission of the disease.

• Authors: K Schubert, A Stein, M Meurer
• Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt) Vol. 53 Issue 7 Pg. 478-82 (Jul 2002) ISSN: 0017-8470 [Print] Germany
• Vernacular Title: Initiales Skleromyxödem Erfolgreiche Therapie mit Melphalan.
• PMID: 12219271 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Prednisolone
• Melphalan

Topics

• Aged
• Biopsy
• Diagnosis, Differential
• Drug Therapy, Combination
• Facial Dermatoses (diagnosis, drug therapy, pathology)
• Female
• Humans
• Lichenoid Eruptions (diagnosis, drug therapy, pathology)
• Melphalan (administration & dosage, adverse effects)
• Myxedema (diagnosis, drug therapy, pathology)
• Prednisolone (administration & dosage, adverse effects)
• Skin (pathology)