Phase 1 clinical study of cyclophilin B peptide vaccine for patients with lung cancer.
|
| Abstract |
Cyclophilin B (CypB) possesses two antigenic epitopes (CypB(84-92) and CypB(91-99) ) recognized by HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes (CTLs). To determine the safety of CypB-derived peptides and its ability to generate antitumor immune responses, patients with advanced lung cancer received subcutaneous vaccinations of these peptides or their modified peptides. All 16 patients were vaccinated with CypB(91-99) or its modified peptide, whereas only two patients were vaccinated with the modified CypB(84-92), as immediate-type hypersensitivity to CypB(84-92) or its modified peptide was observed in the remaining patients. No severe adverse events were associated with the vaccination. No significant increase in cellular responses to either peptides or tumor cells was observed in the postvaccination PBMCs by the conventional CTL assays in any patients tested. These results suggest that the vaccination of CypB(91-99) peptide was safe, but failed to induce objective immune responses at this regimen.
|
|---|---|
| Authors | Rumi Gohara, Nobue Imai, Toru Rikimaru, Akira Yamada, Naoya Hida, Masao Ichiki, Mayumi Kawamoto, Kazuko Matsunaga, Junko Ashihara, Sayoko Yano, Mayumi Tamura, Shinya Ohkouchi, Hideaki Yamana, Kotaro Oizumi, Kyogo Itoh |
| Journal | Journal of immunotherapy (Hagerstown, Md. : 1997) (J Immunother) 2002 Sep-Oct Vol. 25 Issue 5 Pg. 439-44 ISSN: 1524-9557 [Print] United States |
| PMID | 12218782 (Publication Type: Clinical Trial, Clinical Trial, Phase I, Journal Article, Research Support, Non-U.S. Gov't) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!