Abstract | BACKGROUND: METHODS: In a randomized, double-blind, placebo-controlled study, 70 patients received a single dose of oral gabapentin (1,200 mg) or placebo 1 h before surgery. Patients received patient-controlled analgesia with morphine at doses of 2.5 mg with a lock-out time of 10 min for 4 h postoperatively. Pain was assessed on a visual analog scale at rest and during movement, and side effects were assessed on a four-point verbal scale 2 and 4 h postoperatively. RESULTS: Thirty-one patients in the gabapentin group and 34 patients in the placebo group completed the study. Gabapentin reduced total morphine consumption from a median of 29 (interquartile range, 21-33) to 15 (10-19) mg (P< 0.0001). Pain during movement was reduced from 41 (31-59) to 22 (10-38) mm at 2 h postoperatively (P < 0.0001) and from 31 (12-40) to 9 (3-34) mm at 4 h postoperatively (P = 0.018). No significant differences between groups were observed with regard to pain at rest or side effects. CONCLUSION: A single dose of 1,200 mg oral gabapentin resulted in a substantial reduction in postoperative morphine consumption and movement-related pain after radical mastectomy, without significant side effects. These promising results should be validated in other acute pain models involving central neuronal sensitization.
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Authors | Jesper Dirks, Birgitte B Fredensborg, Dennis Christensen, Jonna S Fomsgaard, Henrik Flyger, Jørgen B Dahl |
Journal | Anesthesiology
(Anesthesiology)
Vol. 97
Issue 3
Pg. 560-4
(Sep 2002)
ISSN: 0003-3022 [Print] United States |
PMID | 12218520
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acetates
- Amines
- Analgesics
- Analgesics, Opioid
- Cyclohexanecarboxylic Acids
- gamma-Aminobutyric Acid
- Gabapentin
- Morphine
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Topics |
- Acetates
(administration & dosage, adverse effects, therapeutic use)
- Aged
- Amines
- Analgesics
(administration & dosage, adverse effects, therapeutic use)
- Analgesics, Opioid
(therapeutic use)
- Cyclohexanecarboxylic Acids
- Double-Blind Method
- Female
- Gabapentin
- Humans
- Mastectomy
- Middle Aged
- Morphine
(therapeutic use)
- Pain Measurement
(drug effects)
- Pain, Postoperative
(drug therapy, psychology)
- Treatment Outcome
- gamma-Aminobutyric Acid
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