Effects of long-term administration of enalapril on clinical indicators of renal function in dogs with compensated mitral regurgitation.

Abstract

OBJECTIVE:

To determine the effect of long-term administration of enalapril on renal function in dogs with severe, compensated mitral regurgitation.

DESIGN:

Randomized controlled trial.

ANIMALS:

139 dogs with mitral regurgitation but without overt signs of heart failure.

PROCEDURE:

Dogs were randomly assigned to be treated with enalapril (0.5 mg/kg [0.23 mg/lb], PO, q 24 h) or placebo, and serum creatinine and urea nitrogen concentrations were measured at regular intervals for up to 26 months.

RESULTS:

Adequate information on renal function was obtained from 132 dogs; follow-up time ranged from 0.5 to 26 months (median, 12 months). Mean serum creatinine and urea nitrogen concentrations were not significantly different between dogs receiving enalapril and dogs receiving the placebo at any time, nor were concentrations significantly different from baseline concentrations. Proportions of dogs that developed azotemia or that had a +/- 35% increase in serum creatinine or urea nitrogen concentration were also not significantly different between groups.

CONCLUSIONS:

And Clinical Relevance: Results suggest that administration of enalapril for up to 2 years did not have any demonstrable adverse effects on renal function in dogs with severe, compensated mitral regurgitation.

• Authors: Clarke E Atkins, William A Brown, Julie R Coats, Mary Ann Crawford, Teresa C DeFrancesco, Joel Edwards, Philip R Fox, Bruce W Keene, Linda Lehmkuhl, Michael Luethy, Kate Meurs, Jean-Paul Petrie, Frank Pipers, Steven Rosenthal, Jennifer A Sidley, Justin Straus
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 221 Issue 5 Pg. 654-8 (Sep 01 2002) ISSN: 0003-1488 [Print] United States
• PMID: 12216903 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Enalapril
• Creatinine

Topics

• Angiotensin-Converting Enzyme Inhibitors (adverse effects, therapeutic use)
• Animals
• Blood Urea Nitrogen
• Creatinine (blood)
• Dog Diseases (drug therapy)
• Dogs
• Enalapril (adverse effects, therapeutic use)
• Female
• Follow-Up Studies
• Kidney (drug effects)
• Kidney Function Tests (veterinary)
• Male
• Mitral Valve Insufficiency (complications, drug therapy, veterinary)
• Time Factors