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Immunoglobulin kappa light chain gene alleles are not associated with primary Sjögren's syndrome.

Abstract
The immunoglobulin kappa (Km) light chain gene is polymorphic and is believed to play a role in the pathology of infectious and autoimmune diseases. Polymorphisms within the constant region of the Km gene encode three alleles designated Km1, Km1,2 and Km3. Previous studies using serological detection of Km allotypes reported associations between specific Km allotypes, systemic lupus erythematosus and the presence of anti-La antibodies, yet these findings were not confirmed in other studies. In order to more precisely define any associations between Km alleles and anti-Ro/La antibodies we used the polymerase chain reaction and restriction fragment length polymorphisms for Km genotyping in a large cohort of patients with primary Sjögren's syndrome (SS). No associations were observed between specific Km alleles and primary SS when compared with a control population, nor within serologically defined subsets of SS patients. We conclude that Km alleles are not associated with primary SS or the Ro/La autoantibody response.
AuthorsS Downie-Doyle, S Lester, P Bardy, T Gordon, M Rischmueller, K Pile
JournalGenes and immunity (Genes Immun) Vol. 3 Suppl 1 Pg. S63-5 (Oct 2002) ISSN: 1466-4879 [Print] England
PMID12215905 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Immunoglobulin kappa-Chains
Topics
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Immunoglobulin kappa-Chains (genetics)
  • Polymorphism, Genetic
  • Polymorphism, Restriction Fragment Length
  • Sjogren's Syndrome (genetics, immunology)

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