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Clinical protocol. Tumor site specific phase I evaluation of safety and efficacy of hepatic arterial infusion of a matrix-targeted retroviral vector bearing a dominant negative cyclin G1 construct as intervention for colorectal carcinoma metastatic to liver.

AuthorsHeinz-Josef Lenz, W French Anderson, Frederick L Hall, Erlinda M Gordon
JournalHuman gene therapy (Hum Gene Ther) Vol. 13 Issue 12 Pg. 1515-37 (Aug 10 2002) ISSN: 1043-0342 [Print] United States
PMID12215272 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CCNG1 protein, human
  • Ccng1 protein, mouse
  • Cyclin G
  • Cyclin G1
  • Cyclins
Topics
  • Animals
  • Clinical Protocols
  • Colorectal Neoplasms (genetics, pathology, therapy)
  • Cyclin G
  • Cyclin G1
  • Cyclins (genetics)
  • Genetic Vectors (administration & dosage, pharmacokinetics)
  • Hepatic Artery (pathology)
  • Humans
  • Infusions, Intra-Arterial
  • Liver Neoplasms (genetics, secondary, therapy)
  • Male
  • Mice
  • Mice, Nude
  • Neoplasms, Experimental (genetics, therapy)
  • Retroviridae

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