Abstract | BACKGROUND: OBJECTIVE: To determine whether a similar correlation exists for patients with anterior uveitis caused by VZV. DESIGN: RESULTS: All patients with VZV-induced skin disease alone (control group) displayed intense DH when tested with VZV and PPD antigens. By contrast, only 4 (33%) of 12 patients with ZO-AU had a positive DH to VZV, whereas 11 (91.6%) of these patients displayed positive PPD skin reactions. The clinical intensity of anterior uveitis correlated negatively with VZV DH responses (P<.05). Serum anti-VZV and anti-herpes simplex virus antibody titers were comparable in DH-positive VZV cases and in DH-negative patients with uveitis. Patients with uveitis and ZSH-AU also displayed absent VZV-specific DH, although their PPD responses were normal. MAIN OUTCOME MEASURES: Varicella-zoster virus-specific DH, PPD-specific DH, VZV-specific antibody titration, and intraocular pressure in patients with ZO-AU. CONCLUSIONS: CLINICAL RELEVANCE: In a clinical setting, absence of virus-specific DH to anterior uveitis caused by VZV may not only reveal a possible pathogenic mechanism, but a negative DH response may prove useful in diagnosing ZSH-AU in the acute stage.
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Authors | Takeshi Kezuka, Jun-Ichi Sakai, Hiroshi Minoda, Masaru Takeuchi, Hiroshi Keino, J Wayne Streilein, Masahiko Usui |
Journal | Archives of ophthalmology (Chicago, Ill. : 1960)
(Arch Ophthalmol)
Vol. 120
Issue 9
Pg. 1183-8
(Sep 2002)
ISSN: 0003-9950 [Print] United States |
PMID | 12215092
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antibodies, Viral
- Antigens, Viral
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Topics |
- Acute Disease
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Viral
(blood)
- Antigens, Viral
(immunology)
- Aqueous Humor
(immunology)
- Female
- Herpes Zoster Ophthalmicus
(immunology)
- Herpesvirus 3, Human
(immunology)
- Humans
- Hypersensitivity, Delayed
(immunology)
- Intraocular Pressure
- Male
- Middle Aged
- Polymerase Chain Reaction
- Skin Tests
- Uveitis, Anterior
(immunology, virology)
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