HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Cancer immunotherapy targeting WT1 protein.

Abstract
The Wilms tumor gene WT1 is expressed in leukemias and various kinds of solid tumors, including lung and breast cancer, and exerts an oncogenic function in these malignancies, suggesting that WT1 protein is a novel, overexpressed tumor antigen. The WT1 protein, in fact, is an attractive tumor rejection antigen in animal models. Stimulation in vitro of peripheral blood mononuclear cells with HLA-A*2402--and HLA-A*0201--restricted 9-mer WT1 peptides elicits WT1-specific cytotoxic T-lymphocytes (CTLs), and the CTLs kill endogenously WT1-expressing leukemia or solid tumor cells. Furthermore, WT1 immunoglobulin M (IgM) and IgG antibodies are detected in patients with hematopoietic malignancies such as acute myeloid leukemia, chronic myeloid leukemia, and myelodysplastic syndromes, indicating that WT1 protein overexpressed by leukemia cells is indeed immunogenic. Taken together, these results demonstrate that WT1 protein is a promising tumor antigen for cancer immunotherapy against leukemias and various kinds of solid tumors, including lung and breast cancer.
AuthorsHaruo Sugiyama
JournalInternational journal of hematology (Int J Hematol) Vol. 76 Issue 2 Pg. 127-32 (Aug 2002) ISSN: 0925-5710 [Print] Japan
PMID12215010 (Publication Type: Journal Article, Review)
Chemical References
  • Antigens, Neoplasm
  • WT1 Proteins
Topics
  • Animals
  • Antibody Formation
  • Antigens, Neoplasm (immunology)
  • Humans
  • Immunotherapy (methods)
  • Neoplasms (etiology, therapy)
  • T-Lymphocytes, Cytotoxic (immunology)
  • WT1 Proteins (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: