Antioxidant properties of cabergoline: inhibition of brain auto-oxidation and superoxide anion production of microglial cells in rats.

Abstract

We evaluated the effect of cabergoline on superoxide anion production by rat microglial cells using a 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1, 2-a]pyrazin-3-one-dependent chemiluminescence assay. Cabergoline dose-dependently inhibited superoxide anion production by microglial cells stimulated with phorbol myristate acetate or opsonized zymosan, while it had no superoxide dismutase-like activity. We also studied the effects of cabergoline and alpha-tocopherol on thiobarbituric acid reactive substances formation in homogenized brain-tissue in rats. Cabergoline was stronger than alpha-tocopherol in inhibiting auto-oxidation. While cabergoline is commonly used to treat the motor dysfunction of Parkinson's disease, it may also be effective in inhibiting oxidative stress, a possible mechanism of dopaminergic neuronal degeneration in Parkinson's disease.

• Authors: Toshihiko Yoshida, Makoto Tanaka, Yoko Suzuki, Makoto Sohmiya, Koichi Okamoto
• Journal: Neuroscience letters (Neurosci Lett) Vol. 330 Issue 1 Pg. 1-4 (Sep 13 2002) ISSN: 0304-3940 [Print] Ireland
• PMID: 12213620 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antioxidants
• Ergolines
• Superoxides
• Vitamin E
• Cabergoline

Topics

• Animals
• Animals, Newborn
• Antioxidants (pharmacology)
• Brain (cytology, drug effects, metabolism)
• Cabergoline
• Cells, Cultured
• Dose-Response Relationship, Drug
• Ergolines (pharmacology)
• Male
• Microglia (cytology, drug effects, metabolism)
• Oxidation-Reduction (drug effects)
• Rats
• Rats, Wistar
• Superoxides (metabolism)
• Vitamin E (pharmacology)