[Preventive effect of cardiomyopeptidin on rat heart injured by ischemia-reperfusion].

Abstract

OBJECTIVE:

To investigate the preventive effect of cardiomyopeptidin of small molecular weight polypeptide on rat hearts injured by ischemia-reperfusion.

METHODS:

In a rat model injured by ischemia-reperfusion in the heart, observation was made on the influence of cardiomyopeptidin on the activities of creatine kinase (CK) and lactate dehydrogenase(LDH), as well as on the content of MDA in plasma after the preventive drug was used.

RESULTS:

Cardiomyopeptidin could obviously prevent the injury caused by ischemia-reperfusion, reduce the activities of CK and LDH and the content of MDA in a dose-dependent manner.

CONCLUSION:

Cardiomyopeptidin has a preventive effect on myocardium injured by ischemia-reperfusion and this may be related to its reducing the release of myocardial enzyme and anti-lipoperoxidation.

• Authors: L P Yang, H Y Wan, X P Kong, Y Wu, J Teng, L L Fan
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 25 Issue 2 Pg. 105-7 (Feb 2000) ISSN: 1001-5302 [Print] China
• PMID: 12212070 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Materia Medica
• Peptides
• cardiomyopeptidin
• Malondialdehyde
• L-Lactate Dehydrogenase
• Creatine Kinase

Topics

• Animals
• Creatine Kinase (blood)
• Female
• L-Lactate Dehydrogenase (blood)
• Male
• Malondialdehyde (blood)
• Materia Medica (therapeutic use)
• Molecular Weight
• Myocardial Reperfusion Injury (blood, prevention & control)
• Myocardium (chemistry)
• Peptides (chemistry, therapeutic use)
• Rats
• Rats, Wistar
• Swine