| Abstract | OBJECTIVE: To evaluate the long-term efficacy and possible side effects of low doses of iodized oil on iodine nutrition and thyroid function in endemic goiter in Romania. METHODS: Random selection of 214 schoolchildren aged 6-14 years. Serial measurements of urinary iodine, thyroid volume with ultrasound, serum concentrations of thyrotropin, free thyroxine, thyroglobulin and thyroid autoantibodies before and up to 2 years after the oral administration of 200 mg iodine in iodized oil. RESULTS: Urinary iodine concentrations indicated a moderate iodine deficiency before therapy, sharply increased soon after therapy and slowly decreased thereafter but remained within the normal range up to more than 1 year after therapy. The prevalence of goiter was 29% before the administration of iodized oil and 9% 1 year later. Thyroid function tests and autoantibodies were normal before and up to 2 years after therapy. CONCLUSION: A single dose of 200 mg iodine from oral Lipiodol appears adequate and safe for correcting moderate iodine deficiency in children. |
| Authors | M Simescu, M Varciu, E Nicolaescu, D Gnat, J Podoba, M Mihaescu, F Delange
(Affiliation: Institute of Endocrinology, Bucharest, Romania.)
|
| Journal | Hormone research
(Horm Res)
Vol. 58
Issue 2
Pg. 78-82
( 2002)
ISSN: 0301-0163 Switzerland |
| PMID | 12207166
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
| Copyright | Copyright 2002 S. Karger AG, Basel |
| Chemical References |
- Sodium Chloride, Dietary
- Thyroxine
- Iodine
- Iodized Oil
- Thyrotropin
- Iodide Peroxidase
|
| Topics |
- Adolescent
- Child
- Female
- Goiter, Endemic
(diet therapy)
- Humans
- Iodide Peroxidase
(blood, immunology)
- Iodine
(urine)
- Iodized Oil
(administration & dosage, adverse effects, therapeutic use)
- Male
- Romania
- Sodium Chloride, Dietary
- Thyroid Function Tests
- Thyrotropin
(blood)
- Thyroxine
(blood)
|
