Comparative in vitro activity of faropenem and 11 other antimicrobial agents against 405 aerobic and anaerobic pathogens isolated from skin and soft tissue infections from animal and human bites.

Abstract

Faropenem, a new oral beta-lactam agent with a penem structure, was very active against 405 aerobic and anaerobic bite isolates. It inhibited 232 of 236 (98%) aerobic isolates, including all Pasteurella spp. and Eikenella corrodens at < or = 0.25 mg/L, and 164/169 (97%) anaerobic isolates, at < or = 1 mg/L. The 10 isolates that required > or = 2 mg/L for inhibition were one strain each of Acinetobacter lwoffi, Corynebacterium minutissimum, Bacteroides ovatus, Lactobacillus delbrueckii and Peptostreptococcus tetradius, plus Corynebacterium 'aquaticum' (two strains) and Veillonella sp. (three strains).

• Authors: Ellie J C Goldstein, Diane M Citron, C Vreni Merriam, Yumi A Warren, Kerin L Tyrrell, Helen T Fernandez
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 50 Issue 3 Pg. 411-20 (Sep 2002) ISSN: 0305-7453 [Print] England
• PMID: 12205068 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents
• Fluoroquinolones
• Lactams
• Macrolides
• Tetracyclines
• beta-Lactams
• fropenem

Topics

• Animals
• Anti-Bacterial Agents (pharmacology)
• Anti-Infective Agents (pharmacology)
• Bacteria, Aerobic (drug effects, isolation & purification)
• Bacteria, Anaerobic (drug effects, isolation & purification)
• Bacterial Infections (microbiology)
• Bites and Stings (microbiology)
• Fluoroquinolones
• Humans
• Lactams
• Macrolides
• Skin Diseases, Bacterial (microbiology)
• Tetracyclines
• beta-Lactams