Aloe arborescens extract inhibits TPA-induced ear oedema, putrescine increase and tumour promotion in mouse skin.

Abstract

The ethyl acetate extract of the acetone-soluble Aloe arborescens fraction was found to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear oedema, putrescine increase and tumour promotion in mouse skin. Chromatographic analyses of this extract revealed that phenolic compounds such as aloenin, barbaloin and isobarbaloin could be useful as cancer chemopreventive agents against tumour promotion.

• Authors: Kan Shimpo, Chikako Ida, Takeshi Chihara, Hidehiko Beppu, Takaaki Kaneko, Hiroshi Kuzuya
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 16 Issue 5 Pg. 491-3 (Aug 2002) ISSN: 0951-418X [Print] England
• PMID: 12203274 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2002 John Wiley & Sons, Ltd.

Chemical References

• Anti-Inflammatory Agents
• Antineoplastic Agents
• Plant Extracts
• 9,10-Dimethyl-1,2-benzanthracene
• Tetradecanoylphorbol Acetate
• Putrescine

Topics

• 9,10-Dimethyl-1,2-benzanthracene (pharmacology)
• Aloe (chemistry)
• Animals
• Anti-Inflammatory Agents (pharmacology)
• Antineoplastic Agents (pharmacology)
• Ear (pathology)
• Edema (chemically induced, drug therapy)
• Female
• Mice
• Mice, Inbred ICR
• Plant Extracts (pharmacology)
• Plant Leaves
• Plants, Medicinal
• Putrescine (metabolism)
• Skin Neoplasms (chemically induced, metabolism, pathology)
• Tetradecanoylphorbol Acetate (antagonists & inhibitors, pharmacology)