Sulthiame in adults with refractory epilepsy and learning disability: an open trial.

Abstract

This prospective uncontrolled open study explored the efficacy and long-term tolerability of sulthiame (STM) in 52 patients with refractory epilepsy and learning disability. Thirty-six patients completed a 14-weeks trial period with STM and 22 patients achieved a seizure reduction>50% of which three became seizure-free. Twenty-six patients continued taking STM for now up to 120 weeks, one continued to be seizure-free, whilst five patients stopped STM during this period. These promising observations require further evaluation in a controlled trial.

• Authors: Matthias J Koepp, Phillip N Patsalos, Josemir W A S Sander
• Journal: Epilepsy research (Epilepsy Res) Vol. 50 Issue 3 Pg. 277-82 (Aug 2002) ISSN: 0920-1211 [Print] Netherlands
• PMID: 12200218 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Thiazines
• sulthiame

Topics

• Adult
• Epilepsy (drug therapy)
• Female
• Follow-Up Studies
• Humans
• Learning Disabilities (drug therapy)
• Male
• Middle Aged
• Neutropenia (chemically induced)
• Patient Dropouts
• Prospective Studies
• Thiazines (adverse effects, blood, therapeutic use)
• Treatment Outcome
• Urinary Retention (chemically induced)