[Correction by nicotinamide and nicotinoyl-GABA of dopamine metabolism in rat brain in experimental Parkinson's disease].

Abstract

It was established, that serotonin and dopamine content and dopamine uptake by brain nerve endings under experimental parkinsonism are decreased. Nicotinamide nicotinoyl-GABA administration leads to normalization these parameters. It was shown that NAm was more effective on serotonin content while nicotinoyl-GABA on dopamine one. Dopamine uptake was impaired at experimental parkinsonism and partially was normalized by incubation with NAD (10(-6) M). Thus, NAm, nicotinoyl-GABA and NAD are involved in the regulation of brain neurotransmission under experimental parkinsonism and can be useful in treatment of Parkinson's disease.

• Authors: T M Kuchmerovs'ka, H V Donchenko, H I Fomenko, H V Chichkovs'ka, L V Pakirbaieva, A N Klymenko
• Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) (Ukr Biokhim Zh (1999)) 2001 Nov-Dec Vol. 73 Issue 6 Pg. 108-12 Ukraine
• Vernacular Title: Korektsiia nikotynamidom ta nikotynoïl-HAMK obminu dofaminu v holovnomu mozku shchuriv za eksperymental'noho parkinsonizmu.
• PMID: 12199067 (Publication Type: English Abstract, Journal Article)

Chemical References

• Niacinamide
• Serotonin
• gamma-Aminobutyric Acid
• Dopamine

Topics

• Animals
• Brain (drug effects, metabolism)
• Disease Models, Animal
• Dopamine (metabolism)
• Male
• Niacinamide (pharmacology)
• Parkinson Disease (metabolism)
• Rats
• Rats, Wistar
• Serotonin (metabolism)
• gamma-Aminobutyric Acid (pharmacology)