Abstract | BACKGROUND: OBJECTIVE: The objective of this study was to determine whether the presence of infection alters the PEM-induced reduction in whole-body protein metabolism. DESIGN: We determined whole-body leucine kinetics in 4 boys and 3 girls aged 6-15 mo with edematous PEM and infection approximately 3 d after admission (study 1), when they were both infected and malnourished; approximately 11 d after admission (study 2), when infection had resolved but they were still anthropometrically malnourished; and at recovery (study 3), when weight-for-length was at least 90% of that expected. RESULTS: The children had significantly less leucine flux in both study 1 and study 2 than they had in study 3. There were no significant differences in the amount of leucine released from protein breakdown or used for protein synthesis between study 1 and study 2. There were no significant differences in leucine balance or in either the amount or percentage of enteral leucine extracted by the splanchnic tissues among the 3 studies. CONCLUSIONS: When subjects are in the fed state, severe PEM induces a marked reduction in whole-body protein synthesis and breakdown rates, and the presence of infection does not alter this adaptation and hence the overall protein balance. A corollary is that children with severe PEM do not mount a protein catabolic response to infection.
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Authors | Marvin Reid, Asha Badaloo, Terrence Forrester, William C Heird, Farook Jahoor |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 76
Issue 3
Pg. 633-40
(Sep 2002)
ISSN: 0002-9165 [Print] United States |
PMID | 12198011
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Keto Acids
- Proteins
- alpha-ketoisocaproic acid
- Deuterium
- Leucine
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Topics |
- Deuterium
- Edema
(complications)
- Female
- Humans
- Infant
- Infections
(complications)
- Keto Acids
(blood)
- Kinetics
- Leucine
(metabolism)
- Male
- Protein Biosynthesis
- Protein-Energy Malnutrition
(complications, metabolism, therapy)
- Proteins
(metabolism)
- Splanchnic Circulation
- Weight Gain
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