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Update on complement in the pathogenesis of systemic lupus erythematosus.

Abstract
Complement is involved in inflammation and in the optimization of adaptive responses. Abnormalities in the complement system have been associated with autoimmunity, especially systemic lupus erythematosus. A paradoxic relation exits between complement and lupus. Complement-mediated tissue damage is accepted as a mechanism in disease pathophysiology. Conversely, complement exerts a protective effect in disease development. The theoretic framework explaining this protective influence involves the adequate disposal of apoptotic material by classic pathway components. Inadequate clearance of apoptotic material may evoke a proinflammatory autoimmune response. This conceptual model is substantiated by studies indicating that complement receptor genes are within major susceptibility loci of systemic lupus erythematosus, that functional and structural abnormalities in these receptors are found in lupus mouse models, and that genetic polymorphism of lectin pathway genes correlates with increased risk of disease development. Finally, new diagnostic and therapeutic modalities based on complement regulation have been described in the past year.
AuthorsHector Molina
JournalCurrent opinion in rheumatology (Curr Opin Rheumatol) Vol. 14 Issue 5 Pg. 492-7 (Sep 2002) ISSN: 1040-8711 [Print] United States
PMID12192243 (Publication Type: Journal Article, Review)
Chemical References
  • Complement System Proteins
Topics
  • Animals
  • Complement Activation (physiology)
  • Complement System Proteins (physiology)
  • Disease Models, Animal
  • Humans
  • Lupus Erythematosus, Systemic (etiology, physiopathology)

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