Enhancement of circulatory antioxidants by fenugreek during 1,2-dimethylhydrazine-induced rat colon carcinogenesis.

Abstract

We have investigated the modulatory effect of fenugreek seeds (a spice) on circulatory lipid peroxidation (LPO) and antioxidant status during 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in male Wistar rats. Enhanced LPO in the circulation of tumor bearing animals was accompanied by a significant decrease in the levels of ascorbic acid, vitamin E, reduced glutathione, glutathione peroxidase, glutathione S-transferase, superoxide dismutase and catalase. Inclusion of fenugreek in the diet significantly decreased LPO with simultaneous enhancement of circulating antioxidants. We report that fenugreek exert its chemopreventive effect by decreasing circulatory LPO and enhancing antioxidant levels.

• Authors: T Devasena, Venugopal P Menon
• Journal: Journal of biochemistry, molecular biology, and biophysics : JBMBB : the official journal of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) (J Biochem Mol Biol Biophys) Vol. 6 Issue 4 Pg. 289-92 (Aug 2002) ISSN: 1025-8140 [Print] England
• PMID: 12186747 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkylating Agents
• Antioxidants
• Catalase
• Glutathione Peroxidase
• Superoxide Dismutase
• Glutathione Transferase
• 1,2-Dimethylhydrazine

Topics

• 1,2-Dimethylhydrazine (pharmacology)
• Alkylating Agents (pharmacology)
• Animals
• Antioxidants (pharmacology)
• Catalase (metabolism)
• Colonic Neoplasms (metabolism)
• Glutathione Peroxidase (metabolism)
• Glutathione Transferase (metabolism)
• Male
• Rats
• Rats, Wistar
• Seeds
• Superoxide Dismutase (metabolism)
• Trigonella (chemistry)